International Meeting for Autism Research: Elevated Leptin and Reduced Adiponectin Levels In Omani Autistic Children

Elevated Leptin and Reduced Adiponectin Levels In Omani Autistic Children

Thursday, May 12, 2011
Elizabeth Ballroom E-F and Lirenta Foyer Level 2 (Manchester Grand Hyatt)
1:00 PM
M. E. Mohamed-Musthafa1,2,3, G. J. Guillemin2, M. I. Waly4, A. Ali5, Y. Y. Al-Farsi5, M. M. Al-Sharbati5, N. Braidy2 and M. Al-Shafaee5, (1)Muscat, Sultan Qaboos University, Oman, Sultanate of Oman, Oman, (2)Pharmacology, UNSW, Sydney, Australia, (3)Neurochemistry, NYSIBR, Staten Island, NY, (4)Sultan Qaboos University, Al-Khoud, Oman, (5)Sultan Qaboos University, Muscat, Oman
Background:  Autism is a severe neurodevelpomental disorder with onset prior to 3 years of age and several factors have been implicated in the etiology of autism, including genetic, environmental, autoimmune and inflammatory factors. Studies suggest that abnormal levels of leptin have been implicated in autism and other neuropsychiatric disorders. And also adipokines, such as adiponectin, may play a role in the pathophysiology of autism. No such biochemical data is available for normal and autistic children in Sultanate of Oman

Objectives:  This study was aimed to compare the circulatory levels of leptin and adiponectin in normal and Omani autistic children.

Methods:  The blood/plasma samples were collected from SQU hospital, Oman from autistic and control children.  THe study was approved by SQU ethical committee. Quantitation leptin and adiponectin were done by using the kits from R & D systems, USA

Results:  Reduced adiponectin and elevated leptin were found in Omani autistic children as compared with controls.

Conclusions:  This is the first study in Omani autistic children about leptin and adiponectin. The outcome of this study may give a lead to develop novel biomarkers for early detection of autism. Also this study will give the relationship between adiponectin / leptin and the pathophysiology of autism.

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