Maternal Chemical and Drug Intolerance: A Risk Factor for Autism and ADHD?

Thursday, May 17, 2012
Sheraton Hall (Sheraton Centre Toronto)
1:00 PM
R. F. Palmer1, L. Heilbrun2 and C. S. Miller1, (1)Family and Community Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, (2)Familiy and Community Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX
Background:  Chemical intolerance—the inability to tolerate a wide variety of everyday chemical exposures (fragrances, auto exhaust, cleaning compounds, etc.)—has been associated in numerous studies with multi-system symptoms including: asthma, chronic fatigue, cognitive and memory problems, etc.

Objectives: The primary objective of this study was to investigate the possible association between maternal chemical intolerance as a risk factor for Attention Deficit/ Hyperactivity Disorder (AD/HD) and Autism Spectrum Disorder (ASD). 

Methods: A case-control study was used to test the hypothesis that mothers of children with AD/HD or ASD would score higher on the Quick Environmental Exposure and Sensitivity Inventory (QEESI©)—a  validated tool for diagnosing chemical intolerance—than mothers whose children do not have either ASD or AD/HD. Mothers with (n=183) and without (n=146) AD/HD children, and mothers with (n=282) and without (n=72) ASD children participated in separate surveys. 

Results: Compared to control mothers, case mothers had significantly higher mean scale scores for Chemical Intolerance (p < .001), Other Intolerances (food, drug, caffeine, alcohol etc.) (p=.006), and Symptoms (p<.001) on the QEESI. 

Conclusions: These preliminary findings suggest a possible association between maternal chemical intolerance, ADHD and ASD. Further, if this association is confirmed by additional studies, the QEESI© may be a useful screening tool to identify mothers at risk for having children with AD/HD and autism, and to reduce this risk through early education and intervention—i.e., removal of suspect exposures prior to and during pregnancy. 

| More