Thursday, May 15, 2008
Champagne Terrace/Bordeaux (Novotel London West)
Background: Genetic heterogeneity and weak effects of individual genes have been the major factors that hinder the search for susceptibility genes in autism spectrum disorders (ASD).
Objectives: To identify the ASD susceptibility genes in homogeneous subgroups using genome-wide association methods.
Methods: We will perform a genome-wide association study using 500 unrelated ASD cases and two sets of controls (500 controls from Germany and 1,000 controls from North America). We have finished the genotyping using the Affymetrix GeneChip Human Mapping 500K Array. The genome-wide association data from the Autism Genetic Resource Exchange Consortium (525 families) will be used to replicate the results from this study. Homogeneous subgroups based on IQ, language and family history will be used in the above analyses.
Results: The results will be reported at the meeting.
Conclusions: The conclusions will be reported at the meeting.