Objectives: The data were collected as part of an ongoing longitudinal MRI study on brain development in autism. In this analysis, we use cross-sectional data from Time 1 to investigate age-related differences in corpus callosum neurodevelopment.
Methods: High-resolution DTI images obtained from a 3T MRI scanner were analyzed on 74 individuals with autism and 41 control subjects. Individuals were broken down into 4 age bins: young children age 3-6, older children age 7-11, adolescents age 12-17, and young adults 18+. Volume and microstructure (fractional anisotropy, mean diffusivity, and axial and radial diffusivity) were compared for the total corpus callosum and subregions.
Results: Significant group by age interaction effects were found in the total and subregional corpus callosum measures of fractional anisotropy (FA) and radial diffusivity (Dr). These effects were driven by an increase in FA and decrease in Dr with age in controls that was absent in autism. A comparison within the autism group surprisingly showed elevated FA in young children compared to older children and adults.
Conclusions: Our cross-sectional findings suggest abnormal age-related white matter developmental trajectories in the corpus callosum in autism. These results suggest early abnormal “maturation” followed by abnormal CC development. The findings indicate white matter pathology in a major interhemispheric communication pathway in autism.