The Infant Brain Imaging Study (IBIS) Network is an NIH funded Autism Center of Excellence and consists of a consortium of 7 universities in the
Brain enlargement has been observed in individuals with autism as early as age 2. Studies of head size using head circumference measurements suggest that the period of brain enlargement is a postnatal event and may occur between 6-12 months of age. In this report, we examined the cross-sectional data from 6 month olds at high risk for autism and typically-developing controls participating in the longitudinal study.
Four clinical sites participated in the data collection: University of North Carolina, Washington University, Children’s Hospital of
Group based comparisons for the high-risk infants compared to controls were completed for the selected brain volumes. Brain volumes examined include intracranial volume (ICV), total brain volume (TBV), cerebrum, cerebellum, cortical lobe volumes, lateral ventricles, and head circumference. Statistical analyses included important covariates such as gender, site, body size, and age at scan. We are currently completing the planned statistical analyses for the 6 month dataset, and are unable to include our findings in this abstract. However, these analyses will be completed well before the conference.
The results from this preliminary cross-sectional analysis will provide new information regarding early brain size in infants at high-risk for autism. This study represents the largest known examination of brain volume in an at-risk population.
*IBIS Network: The IBIS (Infant Brain Imaging Study) Network is an NIH funded Autism Center of Excellence (HDO55741) and consists of a consortium of 7 Universities in the