Objectives: To conduct a comprehensive assessment of CI in ASD through the application of TMS to the motor cortices.
Methods: Adolescents and young adults with ASD (n = 36) and matched controls (n = 34) were administered motor cortical TMS paradigms assessing several aspects of CI (thought to reflect activity at GABAA and GABAB receptors).
Results: There were no differences in CI when comparing ASD and control groups. When comparing ASD subtypes, however, specific CI impairments were found among those who had experienced early language delays.
Conclusions: These findings argue against a broad role for GABA in ASD, but indicate that disruption at GABAA and GABAB receptors may be involved in ASD where there is a delay in language acquisition. While clinical subtyping may be useful to better understanding the neurobiology of ASD, this research also has implications for the proposed use of GABA agonists in the treatment of ASD.
See more of: Neurophysiology
See more of: Brain Structure & Function