Just as autism affects many seemingly unrelated areas of behavior, brain imaging studies have revealed that atypical patterns of activation occur in many distinct regions of the brain. Such findings suggest that atypical neural functioning in autism is not restricted to one region, but rather occurs throughout the brain. Furthermore, numerous brain imaging studies have revealed converging evidence of disrupted connectivity between brain regions in autism. Such evidence includes lower frontal-posterior functional connectivity during task performance, lower structural integrity of white matter pathways, and behavioral impairments on cognitive tasks requiring the integration of distinct brain regions. This scientific panel will present recent work refining this issue through a variety of methods, including resting state functional connectivity, classification algorithms, relations between high definition fiber tracking and behavior, and the effects of disrupted brain circuitry on neural learning processes.