Objectives: To further evaluate this risk factor, we have adapted the rodent polyI:C model for use in the nonhuman primate.
Methods: A modified form of poly(I:C) was delivered to pregnant rhesus monkeys (Macaca mulatta) at the end of either the first or second trimester. A separate control group of pregnant rhesus monkeys received saline injections at these time points. Behavioral development of the MIA-exposed macaque offspring was then systematically evaluated for the first 4 years of life.
Results: MIA-exposed macaque offspring demonstrate atypical repetitive behaviors, vocalizations and social interactions.
Conclusions: MIA in the nonhuman primate model was associated with alterations in brain, behavior and immunological development that resemble features of human neurodevelopmental disorders.