Objectives: The current longitudinal study is a seven year follow-up on 91 individuals with ASD, and it was investigated 1) whether symptoms of FTD during childhood predicted prodromal symptoms of psychosis in adolescence, and 2) whether symptoms of FTD during childhood were associated with higher ASD symptom severity in adolescence.
Methods: ASD symptom severity was assessed in childhood (T1) and seven years later in adolescence (T2), using the Autism Diagnostic Observation Schedule (ADOS). At T1, the Kiddie-Formal Thought Disorder Scale (KFTDS) was used to measure symptoms of FTD. At T2, the Prodromal Questionnaire (PQ) was used to assess (pre)psychotic symptoms.
Results: FTD symptoms at T1 did not predict prodromal symptoms of psychosis at T2. FTD symptoms at T1, especially loose associations predicted severity of autism spectrum disorder at T2 over a period of 7 years.
Conclusions: FTD predicts more severe symptoms of ASD over a period of seven years and appears to be a manifestation of more severe impairment in ASD, but does not predict prodromal symptoms of psychosis.
See more of: Psychiatric/Behavioral Comorbidities
See more of: Symptoms, Diagnosis & Phenotype